Of Mice and Men: the Role of Host Type I Interferon Signaling in Control of Ebola Virus Replication


The unprecedented 2013-2016 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. This seminar will discuss two areas of research regarding EBOV interactions with the host IFN response: 1) the systems biology of MAVS signaling in mice that has revealed tissue-specific MAVS-dependent transcriptional pathways associated with host resistance to EBOV, and 2) examination of specific human IFN-stimulated genes (ISGs) that interact with EBOV and confer host specific-resistance to EBOV infection.


  • Dr Sonja  Best
    Dr Sonja Best, Investigator - Innate Immunity and Pathogenesis Unit